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Chemistry: Chemical con artists foil drug discovery.

作者信息

Baell Jonathan, Walters Michael A

出版信息

Nature. 2014 Sep 25;513(7519):481-3. doi: 10.1038/513481a.

DOI:10.1038/513481a
PMID:25254460
Abstract
摘要

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[1]
The essential roles of chemistry in high-throughput screening triage.

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[2]
Phytochemicals perturb membranes and promiscuously alter protein function.

ACS Chem Biol. 2014-8-15

[3]
What is the likelihood of an active compound to be promiscuous? Systematic assessment of compound promiscuity on the basis of PubChem confirmatory bioassay data.

AAPS J. 2013-4-19

[4]
Chemical and structural features influencing the biological activity of curcumin.

Curr Pharm Des. 2013

[5]
Observations on screening-based research and some concerning trends in the literature.

Future Med Chem. 2010-10

[6]
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

J Med Chem. 2010-4-8

[7]
Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.

J Med Chem. 2010-2-11

[8]
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.

Bioorg Med Chem Lett. 2003-2-10

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