干扰素受体及其在干扰素作用中的角色。
Interferon receptors and their role in interferon action.
作者信息
Grossberg S E, Taylor J L, Kushnaryov V M
机构信息
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226.
出版信息
Experientia. 1989 Jun 15;45(6):508-13. doi: 10.1007/BF01990499.
PMID:2525482
Abstract
Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed.
摘要
干扰素（IFN）蛋白通过特定的细胞表面受体与细胞相互作用，其中一些受体已被纯化和克隆。α干扰素和β干扰素与一种共同受体（I型）结合，而γ干扰素与一种不同的受体（II型）结合。在多种细胞上都已证实存在这两种高亲和力受体，并对干扰素影响细胞生理和基因表达的方式进行了讨论。
Zotero 插件