Rahmanian Mojgan, Jahed Farnaz Sheykhnavaz, Yousefi Behpour, Ghorbani Raheb
J Pak Med Assoc. 2014 Jul;64(7):770-4.
To examine the correlation of zinc and copper serum concentration level, body mass index, age and parity with premature rupture of the membranes.
The cross-sectional study was conducted between 2009 and 2010 at the fertility ward of Amiralmomenin Hospital of Semnan University of Medical Sciences, Iran. It comprised 100 full-term pregnant women with and without premature rupture of the membranes and 50 non-pregnant women as controls The diagnosis of rupture of membranes was made on the basis of gross leakage of fluid within the vagina and a positive nitrazin test. A sample of 5 mL blood was collected. The levels of zinc and copper were determined by an enzyme-linked immunosorbent assay method. Mean values among the three equal groups were compared using standard analysis of variance. Statistical significance was set at p < 0.05.
Pregnant women with (p < 0.027) and without (p < 0.019) premature rupture of the membranes had significantly lower serum zinc concentration than non-pregnant women. Inversely, the maternal serum copper concentration level was higher in both groups of pregnant women than in the controls (p < 0.001). However, the results suggest that the decreased plasma zinc concentration and increased copper concentration in pregnant women were not the cause of premature rupture of the membranes at term.
Zinc and copper concentration levels in maternal serum had no effect on premature rupture of the membranes.
探讨血清锌、铜浓度水平、体重指数、年龄及产次与胎膜早破的相关性。
2009年至2010年在伊朗塞姆南医科大学阿米尔·阿尔莫梅宁医院妇产科病房进行了一项横断面研究。研究对象包括100例足月胎膜早破和未破膜的孕妇以及50例非孕妇作为对照。胎膜早破的诊断基于阴道内有明显液体漏出且石蕊试纸试验呈阳性。采集5ml血液样本。采用酶联免疫吸附测定法测定锌和铜的水平。使用标准方差分析比较三组均值。设定统计学显著性水平为p < 0.05。
胎膜早破孕妇（p < 0.027）和未破膜孕妇（p < 0.019）的血清锌浓度均显著低于非孕妇。相反，两组孕妇的母血铜浓度水平均高于对照组（p < 0.001）。然而，结果表明，孕妇血浆锌浓度降低和铜浓度升高并非足月胎膜早破的原因。
母血中锌和铜的浓度水平对胎膜早破无影响。
