Vukelić Jelka, Kapamadzija Aleksandra, Petrović Djordje, Grujić Zorica, Novakov-Mikić Aleksandra, Kopitović Vesna, Bjelica Artur
Department of Obstetrics and Gynaecology, Clinical Centre of Vojvodina, Novi Sad, Serbia.
Srp Arh Celok Lek. 2012 Jan-Feb;140(1-2):42-6.
Copper is essential micronutrient and has an important role in the human body. The serum copper increases during pregnancy and is doubled at full term. Lower levels of serum copper in pregnancy are connected with some pathological conditions.
The aim of this study was to estimate the levels of serum copper in normal and pathological pregnancies, comparing them with values of serum copper in non-pregnant women, to determine if serum copper is lower in some pathological pregnancies and if this is of some importance.
A total of 2170 plasma samples for copper analyses were made in the following groups: healthy non-pregnant women; healthy pregnant women from the 5th-40th gestational week, during the first delivery stage and during the first three postpartum weeks, in pregnant women with habitual abortion, imminent abortion, abortion in progress, missed abortion (9th-24th weeks), missed labour and premature rupture of membranes (29th-40th weeks). Levels of serum copper were determined by colorimetric technique of bathocuproin with disulphate as a chromogen.
Serum copper values in non-pregnant women range from 11.6-25.8 micromol/L. In healthy pregnant women, there is a constant trend of the increase of serum copper. The mean serum copper values revealed three significant peaks at the 22nd, 27th and 35th gestational week. Serum copper values in the patients with some pathological pregnancies in relation to the serum copper values of the healthy pregnant women were significantly lower.
Serum copper values can be used as an indicator of some pathological pregnancies.
铜是必需的微量营养素，在人体中起着重要作用。孕期血清铜水平会升高，足月时会翻倍。孕期血清铜水平较低与一些病理状况有关。
本研究旨在评估正常妊娠和病理妊娠时的血清铜水平，并与非妊娠女性的血清铜值进行比较，以确定某些病理妊娠时血清铜是否较低以及这是否具有一定意义。
共采集了2170份血浆样本用于铜分析，分组如下：健康非妊娠女性；妊娠第5至40周、第一产程及产后前三周的健康孕妇，习惯性流产、先兆流产、流产中、稽留流产（第9至24周）、过期流产及胎膜早破（第29至40周）的孕妇。血清铜水平采用以硫酸二盐为显色剂的亚铜试剂比色法测定。
非妊娠女性的血清铜值范围为11.6 - 25.8微摩尔/升。健康孕妇血清铜呈持续上升趋势。平均血清铜值在妊娠第22周、27周和35周出现三个显著峰值。与健康孕妇血清铜值相比，某些病理妊娠患者的血清铜值显著较低。
血清铜值可作为某些病理妊娠的指标。
