Oran Mustafa, Tulubas Feti, Mete Rafet, Aydin Murat, Sarikaya Hatice Gul, Gurel Ahmet
J Pak Med Assoc. 2014 Jul;64(7):820-2.
The aims of the present study were to evaluate oxidative status, by investigating the serum Paraoxonase/Arylesterase (PON/ARE) activities along with conjugated dienes in patients with IBS and controls and to confirm the link between oxidative stress and IBS. Thirty IBS patient and 30 healthy subjects were recruited. Total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), PON and ARE activities and conjugated dienes levels were measured. Mean serum PON1 activity was lower in IBS group compared to that of the control group whereas there was no significant difference in ARE activity between IBS and control groups (p < 0.000, p < 0.716, respectively). Serum conjugated diene levels of the IBS group was significantly higher than that of the control group (p < 0.01). The drop in PON activity accompanied with an increase in conjugated diene levels indicate the presence of oxidative stress, a disturbance in prooxidant - antioxidant balance and increased inflammation in IBS patients.
本研究的目的是通过调查肠易激综合征（IBS）患者和对照组的血清对氧磷酶/芳基酯酶（PON/ARE）活性以及共轭二烯来评估氧化状态，并确认氧化应激与IBS之间的联系。招募了30例IBS患者和30名健康受试者。测量了总血清胆固醇、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯（TG）、PON和ARE活性以及共轭二烯水平。IBS组的平均血清PON1活性低于对照组，而IBS组和对照组之间的ARE活性无显著差异（分别为p<0.000，p<0.716）。IBS组的血清共轭二烯水平显著高于对照组（p<0.01）。PON活性下降伴随共轭二烯水平升高表明IBS患者存在氧化应激、促氧化剂-抗氧化剂平衡紊乱和炎症增加。
