Department of Interdisciplinary Research in Science, "Alexandru Ioan Cuza" University of Iasi, Carol I Avenue, No. 11, 700506 Iași, Romania.
Department of Research, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, Carol I Avenue, 20A, 700506 Iași, Romania.
Medicina (Kaunas). 2020 Apr 13;56(4):175. doi: 10.3390/medicina56040175.
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, exhibiting complex and controversial pathological features. Both oxidative stress and inflammation-related reactive oxygen species production may be involved in IBS pathological development. Thus, we focused on several aspects regarding the causes of oxidative stress occurrence in IBS. Additionally, in the molecular context of oxidative changes, we tried to discuss these possible neurological implications in IBS. The literature search included the main available databases (e.g., ScienceDirect, Pubmed/Medline, Embase, and Google Scholar). Articles in the English language were taken into consideration. Our screening was conducted based on several words such as "irritable bowel syndrome", "gut brain axis", "oxidative stress", "neuroendocrine", and combinations. While no consistent evidence suggests clear pathway mechanisms, it seems that the inflammatory response may also be relevant in IBS. The mild implication of oxidative stress in IBS has been described through clinical studies and some animal models, revealing changes in the main markers such as antioxidant status and peroxidation markers. Moreover, it seems that the neurological structures involved in the brain-gut axis may be affected in IBS rather than the local gut tissue and functionality. Due to a gut-brain axis bidirectional communication error, a correlation between neurological impairment, emotional over-responsiveness, mild inflammatory patterns, and oxidative stress can be suggested. Therefore, there is a possible correlation between neurological impairment, emotional over-responsiveness, mild inflammatory patterns, and oxidative stress that are not followed by tissue destruction in IBS patients. Moreover, it is not yet clear whether oxidative stress, inflammation, or neurological impairments are key determinants or in which way these three interact in IBS pathology. However, the conditions in which oxidative imbalances occur may be an interesting research lead in order to find possible explanations for IBS development.
肠易激综合征（IBS）是最常见的功能性胃肠疾病之一，具有复杂和有争议的病理特征。氧化应激和与炎症相关的活性氧产生都可能参与 IBS 的病理发展。因此，我们专注于 IBS 中氧化应激发生的几个原因。此外，在氧化变化的分子背景下，我们试图讨论这些可能在 IBS 中的神经学影响。文献检索包括主要的可用数据库（例如，ScienceDirect、Pubmed/Medline、Embase 和 Google Scholar）。只考虑英语文章。我们的筛选是基于几个词进行的，如“irritable bowel syndrome”、“gut brain axis”、“oxidative stress”、“neuroendocrine”和组合。
虽然没有一致的证据表明明确的途径机制，但炎症反应似乎也与 IBS 相关。通过临床研究和一些动物模型已经描述了 IBS 中氧化应激的轻度影响，揭示了主要标志物（如抗氧化状态和过氧化标志物）的变化。此外，似乎涉及脑-肠轴的神经结构可能在 IBS 中受到影响，而不是局部肠道组织和功能。由于脑-肠轴的双向通信错误，可以推测神经损伤、情绪过度反应、轻度炎症模式和氧化应激之间存在相关性。
因此，在 IBS 患者中，存在神经损伤、情绪过度反应、轻度炎症模式和氧化应激之间的可能相关性，而没有组织破坏。此外，目前尚不清楚氧化应激、炎症或神经损伤是关键决定因素，还是这三者在 IBS 病理中以何种方式相互作用。然而，发生氧化失衡的情况可能是一个有趣的研究线索，以便为 IBS 的发展找到可能的解释。
