Oda T, Taneichi H, Takahashi K, Togashi H, Hangai M, Nakagawa R, Ono M, Matsui M, Sasai T, Nagasawa K, Honma H, Kajiwara T, Takahashi Y, Takebe N, Ishigaki Y, Satoh J
Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Diabet Med. 2015 Feb;32(2):213-9. doi: 10.1111/dme.12589. Epub 2014 Oct 18.
To analyse the effects of thyroid hormones on β-cell function and glucose metabolism in people with prediabetes who are euthyroid.
A total of 111 people who were euthyroid underwent 75-g oral glucose tolerance tests, of whom 52 were assigned to the normal glucose tolerance and 59 to the prediabetes groups. Homeostatic model assessment of β-cell function, insulinogenic index and areas under the curve for insulin and glucose were evaluated as indices of pancreatic β-cell function.
In both groups, BMI, fasting insulin, homeostasis model assessment ratio and HDL cholesterol correlated significantly with all indices of pancreatic β-cell function. Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group. Multiple linear regression analysis showed that free triiodothyronine was an independent variable that had a positive correlation with all indices of β-cell function in the prediabetes group. By contrast, no such correlation was found in the normal glucose tolerance group.
Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.
分析甲状腺激素对甲状腺功能正常的糖尿病前期患者β细胞功能和葡萄糖代谢的影响。
共有111名甲状腺功能正常的人接受了75克口服葡萄糖耐量试验，其中52人被分配到糖耐量正常组，59人被分配到糖尿病前期组。评估β细胞功能的稳态模型评估、胰岛素生成指数以及胰岛素和葡萄糖曲线下面积作为胰腺β细胞功能指标。
在两组中，体重指数、空腹胰岛素、稳态模型评估比率和高密度脂蛋白胆固醇与胰腺β细胞功能的所有指标均显著相关。游离三碘甲状腺原氨酸与糖尿病前期组的所有胰岛素分泌指标呈正相关。多元线性回归分析表明，游离三碘甲状腺原氨酸是糖尿病前期组中与β细胞功能所有指标呈正相关的独立变量。相比之下，糖耐量正常组未发现此类相关性。
游离三碘甲状腺原氨酸与甲状腺功能正常的糖尿病前期患者的基础胰岛素分泌和葡萄糖刺激的胰岛素分泌均相关；因此，甲状腺激素对胰岛素分泌的调节是糖尿病治疗中一个潜在的新治疗靶点。
