Department of Medicine, The 522 Hospital of the Chinese PLA, Luoyang 471003, China.
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Air Force Military Medical University (Fourth Military Medical University), Xi'an 710032, China.
Biomed Res Int. 2020 Feb 12;2020:8161797. doi: 10.1155/2020/8161797. eCollection 2020.
The relationship between normal thyroid function and type 2 diabetes mellitus (T2DM) has been a particular focus for concern. The present study determined the relationship between thyroid hormone levels and the prevalence of diabetic retinopathy (DR) in T2DM patients. A cross-sectional study ( = 633) was performed in Xi'an, Shaanxi Province, China. Subjects were evaluated for anthropometric measurements, thyroid function, and diabetic retinopathy. Logistic regression models were used to assess the relationships between thyroid hormones and DR. Of 633 patients, 243 (38.4%) patients suffered from DR. The prevalence of DR showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) (FT3 quartile 1 group [FT3-Q1] <4.35 pmol/L, FT3 quartile 2 group [FT3-Q2] 4.35-4.70 pmol/L, FT3 quartile 3 group [FT3-Q3] 4.70-5.08 pmol/L, and FT3 quartile 4 group [FT3-Q4] ≥5.08 pmol/L) (56.7%, 42.5%, 33.1%, 23.8%, < 0.001). In comparison with all participants categorized in FT3-Q1, the multivariable adjusted odds ratios (95% confidence interval) of DR in FT3-Q2, FT3-Q3, and FT3-Q4 were 0.587 (0.340-1.012), 0.458 (0.258-0.813), and 0.368 (0.201-0.673), ( = 0.055, = 0.008, = 0.001), respectively. FT3 levels within the normal range are negatively associated with DR in euthyroid patients with type 2 diabetes. Further studies should be aimed at clarifying the relationship between thyroid hormones and T2DM.
甲状腺功能正常与 2 型糖尿病（T2DM）之间的关系一直是特别关注的焦点。本研究旨在确定甲状腺激素水平与 T2DM 患者糖尿病视网膜病变（DR）患病率之间的关系。本研究在中国陕西省西安市进行了一项横断面研究（n=633）。对受试者进行了人体测量学测量、甲状腺功能和糖尿病视网膜病变评估。使用 logistic 回归模型评估甲状腺激素与 DR 之间的关系。在 633 名患者中，243 名（38.4%）患者患有 DR。根据游离三碘甲状腺原氨酸（FT3），DR 的患病率在四分之一位中呈显著下降趋势（FT3 四分位 1 组 [FT3-Q1] <4.35 pmol/L，FT3 四分位 2 组 [FT3-Q2] 4.35-4.70 pmol/L，FT3 四分位 3 组 [FT3-Q3] 4.70-5.08 pmol/L，FT3 四分位 4 组 [FT3-Q4] ≥5.08 pmol/L）（56.7%、42.5%、33.1%、23.8%，<0.001）。与所有归入 FT3-Q1 的参与者相比，FT3-Q2、FT3-Q3 和 FT3-Q4 中 DR 的多变量校正比值比（95%置信区间）分别为 0.587（0.340-1.012）、0.458（0.258-0.813）和 0.368（0.201-0.673）（=0.055，=0.008，=0.001）。甲状腺功能正常范围内的 FT3 水平与甲状腺功能正常的 2 型糖尿病患者的 DR 呈负相关。应进一步研究阐明甲状腺激素与 T2DM 之间的关系。
