Zhao Xin, Sun Jianbin, Xin Sixu, Zhang Xiaomei
Department of Endocrinology, Peking University International Hospital, Beijing 102206, China.
Biomedicines. 2023 Aug 7;11(8):2211. doi: 10.3390/biomedicines11082211.
This study aims to explore the correlation between the free-triiodothyronine (FT3)-to-free-thyroxine (FT4) ratio (FT3/FT4) and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
This study retrospectively analyzed 1729 patients with T2DM hospitalized in the Department of Endocrinology, Peking University International Hospital, from January 2017 to August 2021, including 1075 males and 654 females. In accordance with the FT3/FT4, the patients were divided into three groups.
(1) The levels of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and postprandial blood glucose (PBG) among the three groups were significantly different, with the low FT3/FT4 group having the highest HbA1c, FBG and PBG among the three groups (F = 39.39, < 0.01; F = 27.04, < 0.01; F = 5.76, = 0.03; respectively). (2) The proportion of DKD is the highest in the low FT3/FT4 group and the lowest in the high FT3/FT4 group (χ = 25.83, < 0.01). (3) Logistic regression showed that low FT3/FT4 were independent risk factors for DKD (OR = 2.36, 95 CI% 1.63, 3.43; = 0.01).
A decrease in the FT3/FT4 is an independent predictor of DKD occurrence in patients with T2DM.
本研究旨在探讨2型糖尿病（T2DM）患者游离三碘甲状腺原氨酸（FT3）与游离甲状腺素（FT4）比值（FT3/FT4）与糖尿病肾病（DKD）之间的相关性。
本研究回顾性分析了2017年1月至2021年8月在北京大学国际医院内分泌科住院的1729例T2DM患者，其中男性1075例，女性654例。根据FT3/FT4将患者分为三组。
（1）三组患者的糖化血红蛋白（HbA1c）、空腹血糖（FBG）和餐后血糖（PBG）水平存在显著差异，低FT3/FT4组的HbA1c、FBG和PBG在三组中最高（F = 39.39，P < 0.01；F = 27.04，P < 0.01；F = 5.76，P = 0.03；）。（2）DKD的比例在低FT3/FT4组中最高，在高FT3/FT4组中最低（χ = 25.83，P < 0.01）。（3）Logistic回归显示低FT3/FT4是DKD的独立危险因素（OR = 2.36，95%CI 1.63，3.43；P = 0.01）。
FT3/FT4降低是T2DM患者发生DKD的独立预测因素。
