Cai Tommaso, Pisano Francesca, Magri Vittorio, Verze Paolo, Mondaini Nicola, D'Elia Carolina, Malossini Gianni, Mazzoli Sandra, Perletti Gianpaolo, Gontero Paolo, Mirone Vincenzo, Bartoletti Riccardo
Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
J Sex Med. 2014 Dec;11(12):3085-92. doi: 10.1111/jsm.12699. Epub 2014 Sep 25.
Chronic bacterial prostatitis (CBP) is reported to be a common finding in men with acquired premature ejaculation (PE). The impact of different pathogens on PE development in chronic prostatitis patients is, however, unknown.
To assess a possible link between CBP caused by Chlamydia trachomatis (Ct) and PE.
A consecutive series of 317 patients with clinical and instrumental diagnosis of CBP due to Ct was enrolled (group A) and compared with data obtained from a control group of 639 patients with CBP caused by common uropathogen bacteria (group B). Prostatitis symptoms were investigated with the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), while the ejaculatory status of patients was assessed using the PE Diagnostic Tool (PEDT).
All participants were asked to complete the NIH-CPSI, the International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD), the PEDT, and the Short Form (SF)-36 questionnaires.
Patient groups A and B had comparable scores of NIH-CPSI (P = 0.07), IPSS (P = 0.32), and IIEF-15-EFD (P = 0.33) tests. PE was assessed in 118 patients in group A (37.2%) and in 73 subjects in group B (11.5%). The two groups are different in terms of PE prevalence (P < 0.0002). Compared with group B, group A showed significantly higher scores of the PEDT test (11.3 [±2.6] vs. 4.5 [±2.9], P < 0.0001) and lower scores of the SF-36 tool (96.5 [±1.1] vs. 99.7 [±1.3], P < 0.0001). In our multivariate model assessment, being positive for a Ct infection marker was independently associated with the PEDT score even after adjusting for age, smoking habit, body mass index, and education level (adjusted odds ratio = 3.21; 95% confidence interval: 2.02-4.27; P < 0.003).
Patients affected by CBP due to Ct infection reported higher prevalence of PE and lower quality of life when compared with patients affected by CBP caused by traditional uropathogenic bacteria.
据报道，慢性细菌性前列腺炎（CBP）在获得性早泄（PE）男性中很常见。然而，不同病原体对慢性前列腺炎患者PE发展的影响尚不清楚。
评估沙眼衣原体（Ct）引起的CBP与PE之间的可能联系。
连续纳入317例经临床和仪器诊断为Ct所致CBP的患者（A组），并与639例由常见尿路致病菌引起的CBP对照组患者（B组）的数据进行比较。采用美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）调查前列腺炎症状，同时使用早泄诊断工具（PEDT）评估患者的射精状态。
所有参与者均被要求完成NIH-CPSI、国际勃起功能指数-15勃起功能领域（IIEF-15-EFD）、PEDT和简明健康状况调查（SF-36）问卷。
A组和B组患者的NIH-CPSI（P = 0.07）、国际前列腺症状评分（IPSS，P = 0.32）和IIEF-15-EFD（P = 0.33）测试得分相当。A组118例患者（37.2%）和B组73例患者（11.5%）被评估为PE。两组在PE患病率方面存在差异（P < 0.0002）。与B组相比，A组的PEDT测试得分显著更高（11.3 [±2.6] 对 4.5 [±2.9]，P < 0.0001），而SF-36工具得分更低（96.5 [±1.1] 对 99.7 [±1.3]，P < 0.0001）。在我们的多变量模型评估中，即使在调整年龄、吸烟习惯、体重指数和教育水平后，Ct感染标志物呈阳性仍与PEDT得分独立相关（调整后的优势比 = 3.21；95%置信区间：2.02 - 4.27；P < 0.003）。
与传统尿路致病菌引起的CBP患者相比，因Ct感染导致CBP的患者报告的PE患病率更高，生活质量更低。
