Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
Department of Urology, University of Turin, Turin, Italy.
Investig Clin Urol. 2017 Nov;58(6):460-467. doi: 10.4111/icu.2017.58.6.460. Epub 2017 Oct 31.
The role of (CT) infection in chronic bacterial prostatitis (CBP) is well known. What is unclear is whether there are any differences in the course or clinical outcome of the disease when the cause is CT or other uropathogens.
A series of 311 patients affected by CBP due to CT (cohort A) was compared with a group of 524 patients affected by CBP caused by common uropathogen bacteria (cohort B). All participants completed the following questionnaires: National Institutes of Health Chronic Prostatitis Symptom Index, International Prostate Symptom Score, International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD), Premature Ejaculation Diagnostic Tool (PEDT), and the Short Form 36 (SF-36) Health Survey. All patients were followed with clinical and microbiological evaluations.
After a mean follow-up time of 42.3 months, the number of symptomatic episodes was significantly higher in patients in cohort A than in cohort B (4.1±1.1 vs. 2.8±0.8, p<0.001), and the mean time to first symptomatic recurrence was shorter in cohort A than in cohort B (3.3±2.3 months vs. 5.7±1.9 months, p<0.001). Moreover, scores on the SF-36 tool were significantly lower in cohort A (96.5±1.0 vs. 99.7±1.9, p<0.001) at the first symptomatic recurrence. Cohort A also showed significantly lower scores on the IIEF-15-EFD and PEDT questionnaires at the end of the follow-up period (26.8±2.9 vs. 27.3±3.3, p=0.02 and 11.5±2.3 vs. 4.5±2.8, p<0.001, respectively).
Patients affected by CBP due to CT infection have a higher number of symptomatic recurrences with a more severe impact on quality of life.
众所周知，（CT）感染在慢性细菌性前列腺炎（CBP）中起重要作用。目前尚不清楚当病因是 CT 还是其他尿路病原体时，疾病的病程或临床转归是否存在差异。
将 311 例 CT 引起的 CBP 患者（A 队列）与 524 例常见尿路病原体细菌引起的 CBP 患者（B 队列）进行比较。所有参与者均完成以下问卷：美国国立卫生研究院慢性前列腺炎症状指数、国际前列腺症状评分、国际勃起功能指数-15 项勃起功能域（IIEF-15-EFD）、早泄诊断工具（PEDT）和健康调查简表 36（SF-36）。所有患者均进行临床和微生物学评估，并进行随访。
在平均 42.3 个月的随访后，A 队列中症状发作次数明显多于 B 队列（4.1±1.1 比 2.8±0.8，p<0.001），A 队列中首次症状复发的平均时间也短于 B 队列（3.3±2.3 个月比 5.7±1.9 个月，p<0.001）。此外，在首次症状复发时，A 队列的 SF-36 评分明显低于 B 队列（96.5±1.0 比 99.7±1.9，p<0.001）。在随访结束时，A 队列的 IIEF-15-EFD 和 PEDT 问卷评分也明显较低（26.8±2.9 比 27.3±3.3，p=0.02 和 11.5±2.3 比 4.5±2.8，p<0.001）。
由 CT 感染引起的 CBP 患者症状复发次数更多，对生活质量的影响更严重。
