Parets Sasha E, Bedient Carrie E, Menon Ramkumar, Smith Alicia K
Genetics and Molecular Biology Program, Emory University, Atlanta, GA 30322, USA.
Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Biology (Basel). 2014 Aug 21;3(3):498-513. doi: 10.3390/biology3030498.
The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.
发育过程中建立的表观遗传模式可能会影响一生的基因表达，并增加患慢性病的易感性。早产（妊娠<37周）与从出生到成年的死亡和发病风险增加有关。这篇简短的综述探讨了DNA甲基化在早产（PTB）中的潜在作用及其可能的长期后果，并概述了PTB的核心生理过程以及最近关于PTB的DNA甲基化研究。
