You Haizhen, Shi Junyao, Huang Fangfang, Wei Zhiyun, Jones Gary, Du Wenchong, Hua Jing
Department of Women and Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Women and Children Health Care Institution of Pudong District, Shanghai 200021, China.
Brain Sci. 2023 Jun 11;13(6):940. doi: 10.3390/brainsci13060940.
Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition's aetiology.
发育性协调障碍(DCD)是一种发育障碍,其特征为运动协调受损,常与注意力缺陷障碍、自闭症谱系障碍及其他心理和行为状况同时出现。DCD的病因被认为涉及大脑变化和环境因素,遗传学在其发病机制中也起作用。最近的研究已确定了几个与运动障碍相关的候选基因和遗传因素,包括缺失、拷贝数变异、单核苷酸多态性和表观遗传修饰。本综述概述了DCD基因研究的当前知识,强调了继续研究潜在遗传机制的重要性。虽然有证据表明遗传学对DCD有影响,但证据仍处于早期阶段,目前的许多证据基于对共病状况的研究。进一步研究以更好地理解DCD的遗传基础可能对诊断、治疗以及我们对该病症病因的理解具有重要意义。