甲基纤维素对泊洛沙姆眼用制剂凝胶行为和药物释放的影响。
Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations.
机构信息
Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
Department of Chemical and Biological Engineering, Industrial Membrane Research Institute, University of Ottawa, 161 Louis Pasteur St., Ottawa, ON K1N 6N5, Canada.
出版信息
Int J Biol Macromol. 2015 Jan;72:706-10. doi: 10.1016/j.ijbiomac.2014.09.021. Epub 2014 Sep 23.
The effect of weight average molecular weight (Mw) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various M(w) by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in Mw of MC. PM with highest Mw of MC provides best drug release property among all the formulations. It is evident from this investigation that there is a distinct effect of M(w) of MC on the gelation behavior of PM as well as on the drug release profile of KT from PM-MC based ophthalmic formulations.
考察了甲基纤维素（MC）的重均分子量（Mw）对泊洛沙姆 407（PM）的胶凝行为以及不同 PM 为基础的眼科制剂中酮咯酸氨丁三醇（KT）的体外释放的影响。通过试管倾斜法、紫外可见分光光度法、粘度法和流变学法观察到，使用各种 Mw 的 MC 时，PM 的凝胶化温度略有下降。还观察到，所有制剂的粘度和凝胶强度都随着 MC 的 Mw 的增加而增加。在所有制剂中，Mw 最高的 MC 的 PM 提供了最佳的药物释放性能。从这项研究中可以明显看出，MC 的 Mw 对 PM 的胶凝行为以及 PM-MC 为基础的眼科制剂中 KT 的药物释放曲线有明显的影响。
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