眼部给药中的多糖

Dubashynskaya Natallia, Poshina Daria, Raik Sergei, Urtti Arto, Skorik Yury A

Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, 199004 St. Petersburg, Russia.

Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Petrodvorets, 198504 St. Petersburg, Russia.

Pharmaceutics. 2019 Dec 24;12(1):22. doi: 10.3390/pharmaceutics12010022.

Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

多糖，如纤维素、透明质酸、海藻酸和壳聚糖，以及多糖衍生物，已成功用于增强药物递送，以治疗眼部疾病。多糖的性质可以被广泛修饰，以优化眼部药物制剂，并获得具有改善的生物利用度和定制药理作用的生物相容性和可生物降解药物。本综述讨论了用于克服眼部药物递送相关困难的可用多糖选择，并探讨了基于多糖的药物载体的物理化学性质与其在不同制剂和应用中的效率之间存在依赖性的原因。多糖将继续受到致力于开发有效性和安全性更高的眼科药物的研究人员的极大关注。