Daher Paul, Riachy Edward, Khoury Antoine, Raffoul Lara, Ghorra Claude, Rehayem Caline
Department of Pediatric Surgery, Hotel-Dieu de France University Hospital, Beirut, Lebanon.
Department of Pediatric Surgery, Hotel-Dieu de France University Hospital, Beirut, Lebanon.
J Pediatr Adolesc Gynecol. 2015 Feb;28(1):e5-e7. doi: 10.1016/j.jpag.2014.03.003. Epub 2014 Mar 25.
Growing teratoma syndrome (GTS) consists of germ cell tumors that grow following chemotherapy despite complete eradication of the malignant cells. They can metastasize to any site, particularly the retroperitoneum, mediastinum and cervical region. It typically affects young adults and adolescents. Here we describe the youngest case reported in a 4-year-old girl with an ovarian mixed germ cell tumor who underwent an oophorectomy. Her tumor markers normalized by the end of her chemotherapeutic treatment; however, she developed a retroperitoneal mass that was subsequently resected. Histopathology revealed a mature teratoma, consisting of a GTS. We stress the need for early recognition and treatment of GTS to avoid the subsequent morbidity and mortality associated with it. Although GTS has an excellent prognosis when completely resected, it is essential that the patient be regularly followed-up with serum tumor markers and imaging.
生长性畸胎瘤综合征（GTS）由化疗后尽管恶性细胞已被完全清除仍继续生长的生殖细胞肿瘤组成。它们可转移至任何部位，尤其是腹膜后、纵隔和颈部区域。它通常影响年轻成年人和青少年。在此，我们描述了一名4岁患有卵巢混合性生殖细胞肿瘤并接受了卵巢切除术的女孩，这是报道中最年轻的病例。她的肿瘤标志物在化疗结束时恢复正常；然而，她出现了一个腹膜后肿块，随后进行了切除。组织病理学显示为成熟畸胎瘤，符合生长性畸胎瘤综合征。我们强调需要早期识别和治疗生长性畸胎瘤综合征，以避免与之相关的后续发病率和死亡率。尽管生长性畸胎瘤综合征完全切除后预后良好，但对患者定期进行血清肿瘤标志物检查和影像学检查至关重要。
