Tantitamit Tanitra, U'wais Ala, Huang Kuan-Gen
Department of Obstetrics and Gynecology, Faculty of Medicine, Srinakharinwirot University, Nakhonnayok, Thailand.
Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Al-Karak, Jordan.
Gynecol Minim Invasive Ther. 2020 Aug 1;9(3):150-153. doi: 10.4103/GMIT.GMIT_70_18. eCollection 2020 Jul-Sep.
We report a rare case with the late occurrence of growing teratoma syndrome (GTS). A 24-year-old woman with Grade 3 immature teratoma of ovary underwent complete surgery and chemotherapy. Nineteen years later, she developed hematuria and pelvic mass that was completely resected and pathology revealed mature cystic teratoma. She has regularly followed up with tumor marker and computed tomography every three months. No evidence of disease has been detected throughout 14 years. In addition, we present a brief review of literature of ovarian GTS in the last decade. We have found that advanced stage, high grade, or early recurrence of germ cell tumor (GCT) could be the risk factors of GTS. It tends to appear within 1 year if the patients had the incomplete resection of primary disease. We stress the importance of long-term follow-up after treatment GCT to early recognition and treatment.
我们报告一例罕见的发生较晚的成熟性畸胎瘤综合征（GTS）病例。一名24岁患有卵巢3级未成熟畸胎瘤的女性接受了完整的手术及化疗。19年后，她出现血尿和盆腔肿块，肿块被完整切除，病理显示为成熟囊性畸胎瘤。她每三个月定期进行肿瘤标志物检查和计算机断层扫描随访。在14年的时间里未检测到疾病迹象。此外，我们对过去十年卵巢GTS的文献进行了简要综述。我们发现，生殖细胞肿瘤（GCT）的晚期、高级别或早期复发可能是GTS的危险因素。如果患者原发性疾病切除不完全，GTS往往会在1年内出现。我们强调GCT治疗后长期随访对于早期识别和治疗的重要性。
