Deng Ling-Xiao, Walker Chandler, Xu Xiao-Ming
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Goodman and Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Goodman and Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Brain Res. 2015 Sep 4;1619:104-14. doi: 10.1016/j.brainres.2014.09.038. Epub 2014 Sep 26.
After spinal cord injury (SCI), poor ability of damaged axons of the central nervous system (CNS) to regenerate causes very limited functional recovery. Schwann cells (SCs) have been widely explored as promising donors for transplantation to promote axonal regeneration in the CNS including the spinal cord. Compared with other CNS axonal pathways, injured propriospinal tracts display the strongest regenerative response to SC transplantation. Even without providing additional neurotrophic factors, propriospinal axons can grow into the SC environment which is rarely seen in supraspinal tracts. Propriospinal tract has been found to respond to several important neurotrophic factors secreted by SCs. Therefore, the SC is considered to be one of the most promising candidates for cell-based therapies for SCI. Since many reviews have already appeared on topics of SC transplantation in SCI repair, this review will focus particularly on the rationale of SC transplantation in mediating descending propriospinal axonal regeneration as well as optimizing such regeneration by using different combinatorial strategies. This article is part of a Special Issue entitled SI: Spinal cord injury.
脊髓损伤（SCI）后，中枢神经系统（CNS）受损轴突的再生能力较差，导致功能恢复非常有限。雪旺细胞（SCs）作为有前景的移植供体已被广泛研究，以促进包括脊髓在内的中枢神经系统中的轴突再生。与其他中枢神经系统轴突通路相比，损伤的脊髓固有束对雪旺细胞移植表现出最强的再生反应。即使不提供额外的神经营养因子，脊髓固有轴突也能生长到雪旺细胞环境中，而上行脊髓束中很少见到这种情况。已发现脊髓固有束对雪旺细胞分泌的几种重要神经营养因子有反应。因此，雪旺细胞被认为是脊髓损伤基于细胞治疗最有前景的候选者之一。由于已经有许多关于雪旺细胞移植在脊髓损伤修复中的综述，本综述将特别关注雪旺细胞移植介导下行脊髓固有轴突再生的原理，以及通过使用不同的组合策略优化这种再生。本文是名为“脊髓损伤”特刊的一部分。
