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δ-睡眠诱导肽对生理衰老过程中大鼠脑和血液中抗氧化酶基因表达的影响。

Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.

作者信息

Kutilin D S, Bondarenko T I, Kornienko I V, Mikhaleva I I

机构信息

South Federal University, Rostov-on-Don, Russia.

出版信息

Bull Exp Biol Med. 2014 Sep;157(5):616-9. doi: 10.1007/s10517-014-2628-4. Epub 2014 Sep 26.

DOI:10.1007/s10517-014-2628-4
PMID:25257425
Abstract

Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells. The expression of these genes was shown to decrease during physiological aging of the body.

摘要

对不同年龄组(2至24个月)的大鼠皮下注射剂量为100μg/kg的外源性δ睡眠诱导肽(每月,为期5天的疗程)后,大脑和有核血细胞中SOD 1(Sod1)和谷胱甘肽过氧化物酶1(Gpx1)的基因表达增加。这些基因的表达在身体生理衰老过程中会下降。

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