[δ-睡眠诱导肽对机体生理衰老过程中不同大鼠组织溶酶体膜状态及溶酶体蛋白水解强度的影响]
[Influence of delta-sleep inducing peptide on the state of lysosomal membranes and intensity of lysosomal proteolysis in different rat tissues during physiological aging of the organism].
作者信息
Kutilin D S, Bondarenko T I, Mikhaleva I I
出版信息
Adv Gerontol. 2014;27(3):488-95.
PMID:25826997
Abstract
It is shown that subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) to rats aged 2-24 months in a dose of 100 μg/kg animal body weight by courses of 5 consecutive days per month has a stabilizing effect on the state of lysosomal membranes in rat tissues (brain, heart muscle and liver) at different ontogenetic stages, and this effect is accompanied by increasing intensity of lysosomal proteolysis in these tissues.
摘要
结果表明，每月连续5天、以100μg/kg动物体重的剂量给2至24个月龄的大鼠皮下注射外源性δ-睡眠诱导肽（DSIP），对处于不同个体发育阶段的大鼠组织（脑、心肌和肝脏）中的溶酶体膜状态具有稳定作用，且这一作用伴随着这些组织中溶酶体蛋白水解强度的增加。
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