农场动物血清蛋白质组学及其对人类健康的影响。
Farm animal serum proteomics and impact on human health.
作者信息
Di Girolamo Francesco, D'Amato Alfonsina, Lante Isabella, Signore Fabrizio, Muraca Marta, Putignani Lorenza
机构信息
Department of Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, Rome 00165, Italy.
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy.
出版信息
Int J Mol Sci. 2014 Sep 1;15(9):15396-411. doi: 10.3390/ijms150915396.
Due to the incompleteness of animal genome sequencing, the analysis and characterization of serum proteomes of most farm animals are still in their infancy, compared to the already well-documented human serum proteome. This review focuses on the implications of the farm animal serum proteomics in order to identify novel biomarkers for animal welfare, early diagnosis, prognosis and monitoring of infectious disease treatment, and develop new vaccines, aiming at determining the reciprocal benefits for humans and animals.
由于动物基因组测序的不完整性，与已有大量文献记载的人类血清蛋白质组相比，大多数家畜血清蛋白质组的分析和表征仍处于起步阶段。本综述重点关注家畜血清蛋白质组学的意义，以便识别用于动物福利、早期诊断、预后评估以及传染病治疗监测的新型生物标志物，并开发新疫苗，旨在确定对人类和动物的互惠益处。
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