Porter James N, Roy Amy K, Benson Brenda, Carlisi Christina, Collins Paul F, Leibenluft Ellen, Pine Daniel S, Luciana Monica, Ernst Monique
University of Iowa Hospitals and Clinics Department of Neurology, USA.
Fordham University, Department of Psychology, USA.
Dev Cogn Neurosci. 2015 Feb;11:83-95. doi: 10.1016/j.dcn.2014.08.011. Epub 2014 Aug 30.
The striatum codes motivated behavior. Delineating age-related differences within striatal circuitry can provide insights into neural mechanisms underlying ontogenic behavioral changes and vulnerabilities to mental disorders. To this end, a dual ventral/dorsal model of striatal function was examined using resting state intrinsic functional connectivity (iFC) imaging in 106 healthy individuals, ages 9-44. Broadly, the dorsal striatum (DS) is connected to prefrontal and parietal cortices and contributes to cognitive processes; the ventral striatum (VS) is connected to medial orbitofrontal and anterior cingulate cortices, and contributes to affective valuation and motivation. Findings revealed patterns of age-related changes that differed between VS and DS iFCs. We found an age-related increase in DS iFC with posterior cingulate cortex (pCC) that stabilized after the mid-twenties, but a decrease in VS iFC with anterior insula (aIns) and dorsal anterior cingulate cortex (dACC) that persisted into mid-adulthood. These distinct developmental trajectories of VS vs. DS iFC might underlie adolescents' unique behavioral patterns and vulnerabilities to psychopathology, and also speaks to changes in motivational networks that extend well past 25 years old.
纹状体编码动机行为。描绘纹状体回路中与年龄相关的差异，有助于深入了解个体发育行为变化和精神障碍易感性背后的神经机制。为此，我们利用静息态内在功能连接（iFC）成像技术，对106名年龄在9至44岁的健康个体进行了研究，以检验纹状体功能的腹侧/背侧双模型。一般来说，背侧纹状体（DS）与前额叶和顶叶皮质相连，参与认知过程；腹侧纹状体（VS）与内侧眶额皮质和前扣带回皮质相连，参与情感评估和动机形成。研究结果揭示了VS和DS的iFC中与年龄相关的变化模式存在差异。我们发现，DS与后扣带回皮质（pCC）的iFC随年龄增长而增加，并在二十多岁中期趋于稳定，但VS与前脑岛（aIns）和背侧前扣带回皮质（dACC）的iFC则随年龄下降，并持续到成年中期。VS与DS的iFC这种不同的发育轨迹，可能是青少年独特行为模式和心理病理学易感性的基础，也说明了动机网络在25岁以后仍会发生变化。
