Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101 Rohrdorf, Germany.
Kapriol Bt., Vak Bottyán St. 1, 8330 Sümeg, Hungary.
Parasite. 2021;28:27. doi: 10.1051/parasite/2021023. Epub 2021 Apr 2.
The therapeutic efficacy against notoedric mange of a topical combination of esafoxolaner, eprinomectin and praziquantel (Nexgard Combo, Boehringer Ingelheim) was evaluated in a masked, controlled clinical study including 14 cats with natural or induced Notoedres cati infestation. Cats were allocated randomly to two groups of seven cats each, to be administered either mineral oil (placebo control) or NexGard Combo. Each treatment was administered once as spot-on at 0.12 mL per kg body weight (representing the minimum label dosage of NexGard Combo, i.e. 1.44 mg esafoxolaner, 0.48 mg eprinomectin, and 10.0 mg praziquantel per kg body weight). Live mites were counted in skin scrapings collected within seven days prior to and 14, 27/28, 42 and 56 days after treatment to calculate the percentage efficacy of NexGard Combo based on the comparison of mean live mite counts of the two groups. Concurrently, mange lesions and clinical signs were scored to establish a clinical success valuation. No live mites were recovered from any NexGard Combo-treated cats post-treatment, indicating 100% therapeutic efficacy following a single spot-on administration of the novel antiparasitic combination. The clinical success valuations in the NexGard Combo-treated cats were 14.3%, 42.8%, 100% and 100% at 14, 27/28, 42 and 56 days after treatment, respectively. No health problems were observed throughout the study.
一项针对局部联合应用埃索昔拉菌素、依普菌素和吡喹酮（Nexgard Combo，勃林格殷格翰）治疗诺特氏痒螨病的疗效评估在一项有对照的临床研究中进行，该研究纳入了 14 只患有自然或诱导性猫诺特氏痒螨感染的猫。这些猫被随机分配到两组，每组 7 只，分别给予矿物油（安慰剂对照）或 Nexgard Combo。每种治疗方法均以 0.12 毫升/千克体重的剂量进行一次点涂（代表 Nexgard Combo 的最低标签剂量，即 1.44 毫克埃索昔拉菌素、0.48 毫克依普菌素和 10.0 毫克吡喹酮/千克体重）。在治疗前 7 天和治疗后 14、27/28、42 和 56 天采集皮肤刮片，计算活螨计数，以比较两组的平均活螨计数，计算 Nexgard Combo 的疗效百分比。同时，对螨病病变和临床症状进行评分，以建立临床疗效评估。Nexgard Combo 治疗的猫在治疗后均未检出活螨，单次点涂新型驱虫联合用药后，疗效达到 100%。Nexgard Combo 治疗的猫在治疗后 14、27/28、42 和 56 天的临床疗效评分分别为 14.3%、42.8%、100%和 100%。在整个研究过程中未观察到任何健康问题。
