Jenkinson Michael D, Weber Damien C, Haylock Brian J, Mallucci Conor L, Zakaria Rasheed, Javadpour Mohsen
Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, L9 7LJ, UK,
J Neurooncol. 2015 Jan;121(1):1-7. doi: 10.1007/s11060-014-1620-1. Epub 2014 Sep 26.
Atypical meningioma is an intermediate grade tumour with a greater risk of recurrence following surgical resection. Changes to the WHO classification have resulted in an increased reporting of these tumours. The role of early adjuvant radiotherapy after gross total resection has not been clearly defined and the literature evidence is of poor quality providing conflicting information. This review assesses the evidence for current clinical practice, management dilemmas and the need for prospective clinical trials for atypical meningioma.
非典型脑膜瘤是一种中级别的肿瘤,手术切除后复发风险较高。世界卫生组织(WHO)分类的变化导致这些肿瘤的报告有所增加。大体全切术后早期辅助放疗的作用尚未明确界定,文献证据质量较差且提供了相互矛盾的信息。本综述评估了非典型脑膜瘤当前临床实践的证据、管理困境以及开展前瞻性临床试验的必要性。