Oguh O, Eisenstein A, Kwasny M, Simuni T
Department of Neurology, University of Florida, Jacksonville, FL, USA.
Buehler Center on Aging, Health & Society Northwestern University, Chicago, IL, USA.
Parkinsonism Relat Disord. 2014 Nov;20(11):1221-5. doi: 10.1016/j.parkreldis.2014.09.008. Epub 2014 Sep 16.
There is a substantial interest in the impact of exercise on reduction of disability and rate of progression of Parkinson's disease (PD).
The primary aim was to describe exercise habits of PD patients and factors associated with greater levels of exercise. The secondary aim was to explore whether regular exercise is associated with a slower decline of function, disease-related quality of life, and caregiver burden.
The National Parkinson's Foundation (NPF) QII Registry data was used to analyze variables that correlate with levels of exercise in PD patients across disease severity. Subjects were categorized into three groups: non-exercisers (0 min/week), low exercisers (1-150 min/week), and regular exercisers (>150 min/week). Health related outcomes, disease metrics, and demographic factors associated with exercise were examined using bivariate analyses. Multiple regression models controlled for disease duration, severity, and cognitive function. An exploratory analysis was completed on the association of baseline level of exercise with health outcomes at one year follow up.
4866 subjects were included in the baseline analysis and 2252 subjects who had second visits were included in the longitudinal data. Regular exercisers at baseline were associated with better QOL, mobility, and physical function, less progression of disease, less caregiver burden and less cognitive decline one year later, after controlling for demographic and disease severity variables.
This study provides important preliminary evidence of the beneficial effects of regular exercise in a large PD cohort. Longitudinal studies will be essential to confirm findings.
运动对帕金森病（PD）患者残疾程度降低及疾病进展速率的影响备受关注。
主要目的是描述PD患者的运动习惯以及与更高运动水平相关的因素。次要目的是探究规律运动是否与功能衰退减缓、疾病相关生活质量及照料者负担减轻相关。
利用美国国家帕金森病基金会（NPF）QII注册数据，分析不同疾病严重程度的PD患者中与运动水平相关的变量。受试者被分为三组：不运动者（0分钟/周）、低运动量者（1 - 150分钟/周）和规律运动者（>150分钟/周）。采用双变量分析检查与运动相关的健康结局、疾病指标和人口统计学因素。多元回归模型对疾病持续时间、严重程度和认知功能进行了控制。对基线运动水平与一年随访时健康结局的关联进行了探索性分析。
4866名受试者纳入基线分析，2252名进行第二次随访的受试者纳入纵向数据。在控制人口统计学和疾病严重程度变量后，基线时的规律运动者在一年后与更好的生活质量、运动能力和身体功能、疾病进展减缓、照料者负担减轻及认知衰退减缓相关。
本研究为规律运动对大量PD患者有益提供了重要的初步证据。纵向研究对于证实这些发现至关重要。
