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百里香酚对猬迭宫绦虫四槽蚴和成虫的体外杀绦虫活性

In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms.

作者信息

Maggiore M, Elissondo M C

机构信息

Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), 3350 Funes Street, 7600 Mar del Plata, Argentina ; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

出版信息

Interdiscip Perspect Infect Dis. 2014;2014:268135. doi: 10.1155/2014/268135. Epub 2014 Sep 3.

DOI:10.1155/2014/268135
PMID:25258624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4166659/
Abstract

Nothing is known about the possible effect of thymol or other compounds of essential oils against the adult worms of cestodes. The aim of the present work was to determine in vitro cestodicidal activity of thymol against Mesocestoides corti adult worms. Moreover, the in vitro effect on tetrathyridia was also demonstrated. Tetrathyridia exposed to different concentrations of thymol showed a concentration and time-dependent effect. At lower concentrations, the main change observed was mainly in morphology, with larvae exhibiting an elongation of the body. When tetrathyridia were exposed to higher concentrations, increased surface alterations and damage were detected. The body appeared elongated and flattened, and a complete loss of morphology and microtriches was observed. Thymol was able to kill M. corti tetrathyridia, since following inoculation of treated parasites in mice no parasites could be recovered. The effect on M. corti adult worms was dose and time-dependent. Changes in motility coincide with the tissue damage were observed at the structural and ultrastructural level. Thymol caused severe damages to both developmental stages analyzed. Damages were more significant in fully segmented worms. The data reported in this paper demonstrate a clear in vitro effect of thymol against M. corti tetrathyridia and adult worms.

摘要

关于百里香酚或精油中的其他化合物对绦虫成虫可能产生的影响尚无定论。本研究的目的是确定百里香酚对柯氏中殖孔绦虫成虫的体外杀绦虫活性。此外，还证明了其对四膜虫的体外作用。暴露于不同浓度百里香酚的四膜虫表现出浓度和时间依赖性效应。在较低浓度下，观察到的主要变化主要在形态上，幼虫身体伸长。当四膜虫暴露于较高浓度时，检测到表面改变和损伤增加。虫体变得细长且扁平，形态和微毛完全丧失。百里香酚能够杀死柯氏中殖孔绦虫四膜虫，因为将经处理的寄生虫接种到小鼠体内后无法再找到寄生虫。对柯氏中殖孔绦虫成虫的作用呈剂量和时间依赖性。在结构和超微结构水平上观察到，运动变化与组织损伤一致。百里香酚对所分析的两个发育阶段均造成了严重损害。在完全节段化的虫体中损害更为显著。本文报道的数据表明百里香酚对柯氏中殖孔绦虫四膜虫和成虫具有明显的体外作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/cdc2115f6d8b/IPID2014-268135.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/de61f69fc57d/IPID2014-268135.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/347fb506c1fd/IPID2014-268135.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/98a819d34615/IPID2014-268135.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/cdc2115f6d8b/IPID2014-268135.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/de61f69fc57d/IPID2014-268135.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/347fb506c1fd/IPID2014-268135.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/98a819d34615/IPID2014-268135.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5097/4166659/cdc2115f6d8b/IPID2014-268135.004.jpg

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