Johannesson Liza, Dahm-Kähler Pernilla, Eklind Saskia, Brännström Mats
Department of Obstetrics & Gynecology, Sahlgrenska Academy, University of Gothenburg, Women's Clinic, Carlanderska Hospital, Gothenburg.
Womens Health (Lond). 2014 Jul;10(4):455-67. doi: 10.2217/whe.14.22.
The only untreatable subgroup of female infertility is absolute uterine factor infertility (AUFI), which is due to congenital or surgical absence of a uterus or presence of a nonfunctional uterus. The solitary option for a woman with AUFI to become a biological mother today is through a gestational surrogate mother, a procedure that is prohibited in Sweden and large parts of the world. Uterus transplantation (UTx) is a potential future treatment of AUFI. After extensive animal research, also involving non-human primates, a small number of human UTx cases have recently been performed. Here, we summarize the primate UTx experiments that have paved the way for the human UTx cases, which are described and analyzed in more detail. We also estimate how many women of fertile age are affected by AUFI and describe the causes. The ethics around UTx is complex and is also addressed.
女性不孕症中唯一无法治疗的亚组是绝对子宫因素不孕症（AUFI），其原因是先天性或手术导致子宫缺失或存在无功能的子宫。如今，患有AUFI的女性成为亲生母亲的唯一选择是通过妊娠代孕母亲，但这一程序在瑞典和世界大部分地区都被禁止。子宫移植（UTx）是未来治疗AUFI的一种潜在方法。经过广泛的动物研究，包括对非人类灵长类动物的研究，最近已经进行了少量的人类子宫移植病例。在这里，我们总结了为人类子宫移植病例铺平道路的灵长类动物子宫移植实验，并对其进行了更详细的描述和分析。我们还估计了有多少育龄妇女受AUFI影响，并描述了其病因。围绕子宫移植的伦理问题很复杂，本文也将予以探讨。
