Song Miho, Park Junsoo, Kim Young Hoon, Han Duck Jong, Song Sang Hoon, Choo Myung-Soo, Hong Bumsik
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 138-736, Korea.
Int Urol Nephrol. 2015 Jan;47(1):101-6. doi: 10.1007/s11255-014-0848-1. Epub 2014 Sep 28.
This study evaluated the clinical factors that influence bladder capacity and lower urinary tract dysfunction (LUTD) following kidney transplantation (KT) in end-stage renal disease (ESRD) patients.
Data were analyzed in ESRD patients who underwent KT between January 2011 and January 2013. The analyzed pre-KT parameters include bladder capacity, vesicoureteral reflux (VUR), postvoid residual urine (PVR), micturition frequency, and voiding volume. Associations between pre-KT parameters, small bladder capacity (<100 cc), and parameters that influence the development of LUTD were also evaluated. LUTD after KT was defined as voiding symptoms that lasted >1 month and required specific treatment.
In total, 622 ESRD patients required KT. The mean age and dialysis duration were 43.9±11.2 years and 59.4±60.7 months. The mean bladder capacity before KT was 300.1±149.8 mL, and 14% of patients were diagnosed with small bladder capacity. VUR and PVR were observed in 110 (17.5%) and 83 (13.6%) patients. Factors associated with small bladder capacity included long-term dialysis, presence of VUR, and PVR (p<0.001, p=0.004, p=0.003). After KT, 31 patients (4.9%) needed treatment due to LUTD. Factors associated with the development of LUTD included age, VUR, and PVR (p=0.001 p=0.034, p<0.001). Bladder capacity did not affect LUTD after KT.
ESRD patients on long-term dialysis will likely have small bladder capacity and VUR; however, bladder capacity itself is not related to the occurrence of LUTD after KT.
本研究评估了影响终末期肾病（ESRD）患者肾移植（KT）后膀胱容量及下尿路功能障碍（LUTD）的临床因素。
对2011年1月至2013年1月期间接受KT的ESRD患者的数据进行分析。分析的KT前参数包括膀胱容量、膀胱输尿管反流（VUR）、排尿后残余尿量（PVR）、排尿频率及排尿量。还评估了KT前参数、小膀胱容量（<100 cc）与影响LUTD发生的参数之间的关联。KT后的LUTD定义为持续>1个月且需要特定治疗的排尿症状。
共有622例ESRD患者需要进行KT。平均年龄和透析时间分别为43.9±11.2岁和59.4±60.7个月。KT前平均膀胱容量为300.1±149.8 mL，14%的患者被诊断为小膀胱容量。110例（17.5%）和83例（13.6%）患者观察到VUR和PVR。与小膀胱容量相关的因素包括长期透析、VUR的存在及PVR（p<0.001，p=0.004，p=0.003）。KT后，31例患者（4.9%）因LUTD需要治疗。与LUTD发生相关的因素包括年龄、VUR和PVR（p=0.001，p=0.034，p<0.001）。膀胱容量对KT后的LUTD无影响。
长期透析的ESRD患者可能有小膀胱容量和VUR；然而，膀胱容量本身与KT后LUTD的发生无关。
