是什么决定了移植肝脏的老化？
What determines ageing of the transplanted liver?
作者信息
Hodgson Russell, Christophi Chris
机构信息
Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.
出版信息
HPB (Oxford). 2015 Mar;17(3):222-5. doi: 10.1111/hpb.12339. Epub 2014 Sep 28.
BACKGROUND
Liver transplantation is used to treat patients with irreversible liver failure from a variety of causes. Long-term survival has been reported, particularly in the paediatric population, with graft survival longer than 20 years now possible. The goal for paediatric liver transplantation is to increase the longevity of grafts to match the normal life expectancy of the child. This paper reviews the literature on the current understanding of ageing of the liver and biomarkers that may predict long-term survival or aid in utilization of organs.
METHODS
Scientific papers published from 1950 to 2013 were sought and extracted from the MEDLINE, PubMed and University of Melbourne databases.
RESULTS
Hepatocytes appear resistant to the ageing process, but are affected by both replicative senescence and stress-related senescence. These processes may be exacerbated by the act of transplantation. The most studied biomarkers are telomeres and SMP-30.
CONCLUSION
There are many factors that play a role in the ageing of the liver. Further studies into biomarkers of ageing and their relationship to the chronological age of the liver are required to aid in predicting long-term graft survival and utilization of organs.
背景
肝移植用于治疗由多种病因导致的不可逆性肝衰竭患者。已有长期存活的报道，尤其是在儿科患者中，目前移植物存活超过20年已成为可能。儿科肝移植的目标是提高移植物的寿命，使其与儿童的正常预期寿命相匹配。本文综述了有关目前对肝脏衰老的认识以及可能预测长期存活或有助于器官利用的生物标志物的文献。
方法
检索并从MEDLINE、PubMed和墨尔本大学数据库中提取1950年至2013年发表的科学论文。
结果
肝细胞似乎对衰老过程具有抗性，但会受到复制性衰老和应激相关衰老的影响。这些过程可能会因移植行为而加剧。研究最多的生物标志物是端粒和SMP-30。
结论
有许多因素在肝脏衰老过程中起作用。需要进一步研究衰老的生物标志物及其与肝脏实际年龄的关系，以帮助预测移植物的长期存活和器官的利用。
Zotero 插件