Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
J Clin Invest. 2019 Jan 2;129(1):4-11. doi: 10.1172/JCI123946.
Donor age and recipient age are factors that influence transplantation outcomes. Aside from age-associated differences in intrinsic graft function and alloimmune responses, the ability of young and old cells to exert either rejuvenating or aging effects extrinsically may also apply to the transplantation of hematopoietic stem cells or solid organ transplants. While the potential for rejuvenation mediated by the transfer of youthful cells is currently being explored for therapeutic applications, aspects that relate to accelerating aging are no less clinically significant. Those effects may be particularly relevant in transplantation with an age discrepancy between donor and recipient. Here, we review recent advances in understanding the mechanisms by which young and old cells modify their environments to promote rejuvenation- or aging-associated phenotypes. We discuss their relevance to clinical transplantation and highlight potential opportunities for therapeutic intervention.
供者年龄和受者年龄是影响移植结果的因素。除了与年龄相关的内在移植物功能和同种免疫反应差异外，年轻和老年细胞发挥 rejuvenating 或 aging 效应的能力也可能适用于造血干细胞移植或实体器官移植。虽然通过转移年轻细胞来实现 rejuvenation 的潜力目前正在探索用于治疗应用，但与加速衰老相关的方面在临床上同样重要。这些影响在供者和受者年龄差异较大的移植中可能尤为相关。在这里，我们回顾了理解年轻和老年细胞改变其环境以促进 rejuvenation- 或 aging 相关表型的机制的最新进展。我们讨论了它们与临床移植的相关性，并强调了治疗干预的潜在机会。
