Soumya V, Muzib Y Indira, Venkatesh P, Hariprasath K
Department of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupathi-517502 Andhra Pradesh, India.
Department of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupathi-517502 Andhra Pradesh, India.
Chin J Nat Med. 2014 Sep;12(9):677-84. doi: 10.1016/S1875-5364(14)60103-5.
To evaluate the effect of Cocus nucifera L. flowers in reducing the major multiple symptoms of letrozole-induced polycystic ovarian disease (PCOD) in female rats.
Female, virgin Wistar rats were treated with letrozole (1 mg/kg body wt) to induce PCOD, and after 21 days of induction rats were administered orally with 100 and 200 mg·kg(-1) of Cocus nucifera flower aqueous extract, respectively. Estrus cycle and blood sugar were monitored once a week throughout the study. After scarification, various biochemical parameters, such as antioxidant status (superoxide dismutase (SOD) and glutathione reductase (GSH)) of the uterus homogenate, lipid profile (total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides (TG)) of the serum were determined. Weights of the uterus and ovaries were separately monitored. The characteristics of changes in the ovary were evaluated by histopathological studies.
GC-MS analysis of the aqueous extract showed the presence of volatile and pharmacologically active phytoconstituents. C. nucifera flower extract-treated groups showed estrus cyclicity and increased uterus weight which indicates the estrogenic effect. The improved blood sugar level, ideal lipid profile, good antioxidant status, and histopathology results revealed the recovery from poly cystic ovaries.
The results indicate that C. nucifera flower is a potential medicine for the treatment of PCOD and this study supports the traditional uses of C. nucifera flower.
评估椰花对减轻雌性大鼠来曲唑诱导的多囊卵巢疾病（PCOD）主要多重症状的效果。
将未交配的雌性Wistar大鼠用1mg/kg体重的来曲唑处理以诱导PCOD，诱导21天后，大鼠分别口服100mg·kg(-1)和200mg·kg(-1)的椰花水提取物。在整个研究过程中每周监测一次发情周期和血糖。处死后，测定子宫匀浆的各种生化参数，如抗氧化状态（超氧化物歧化酶（SOD）和谷胱甘肽还原酶（GSH）），血清的脂质谱（总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和甘油三酯（TG））。分别监测子宫和卵巢的重量。通过组织病理学研究评估卵巢变化的特征。
水提取物的气相色谱-质谱分析表明存在挥发性和药理活性植物成分。椰花提取物处理组表现出发情周期性和子宫重量增加，这表明具有雌激素作用。血糖水平改善、脂质谱理想、抗氧化状态良好以及组织病理学结果显示从多囊卵巢中恢复。
结果表明椰花是治疗PCOD的潜在药物，本研究支持椰花的传统用途。
