一种来自连翘的新木脂素糖苷。

A new lignan glycoside from Forsythia suspensa.

作者信息

Li Chang, Dai Yi, Duan Ying-Hui, Liu Ming-Li, Yao Xin-Sheng

机构信息

College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.

出版信息

Chin J Nat Med. 2014 Sep;12(9):697-9. doi: 10.1016/S1875-5364(14)60107-2.

DOI:10.1016/S1875-5364(14)60107-2

PMID:25263983

Abstract

Phytochemical investigation on Forsythia suspensa (Thunb.) Vahl afforded ten compounds, including five lignan glycosides and five phenylethanoid glycosides. The compounds were isolated by using HP-20 macroporous resin, silica gel, octadecyl silica gel (ODS), size exclusion chromatography resin HW-40 chromatography, and preparative HPLC. The structures were established through application of extensive spectroscopic methods, including ESI-MS, 1D-and 2D-NMR spectroscopy. They were identified as forsythialanside E (1), 8'-hydroxypinoresinol-4'-O-β-D-glucoside (2), 8'-hydroxypinoresinol (3), lariciresinol-4'-O-β-D-glucoside (4), lariciresinol-4-O-β-D-glucoside (5), forsythoside H (6), forsythoside I (7), forsythoside F (8), plantainoside B (9), and plantainoside A (10). Compound 1 was a new lignan glycoside.

摘要

对连翘进行植物化学研究，得到了10种化合物，包括5种木脂素糖苷和5种苯乙醇苷。这些化合物通过使用HP - 20大孔树脂、硅胶、十八烷基硅胶（ODS）、尺寸排阻色谱树脂HW - 40色谱和制备型高效液相色谱进行分离。通过应用广泛的光谱方法，包括电喷雾电离质谱（ESI - MS）、一维和二维核磁共振光谱（1D - 和2D - NMR）确定了其结构。它们被鉴定为连翘脂苷E（1）、8'-羟基松脂醇 - 4'-O-β-D-葡萄糖苷（2）、8'-羟基松脂醇（3）、落叶松脂醇 - 4'-O-β-D-葡萄糖苷（4）、落叶松脂醇 - 4 - O-β-D-葡萄糖苷（5）、连翘苷H（6）、连翘苷I（7）、连翘苷F（8）、大车前苷B（9）和大车前苷A（10）。化合物1是一种新的木脂素糖苷。