Validation of a triglyceride meter for use in pregnancy.

BACKGROUND

Elevated maternal triglycerides have been associated with adverse pregnancy outcomes including an increased risk of preeclampsia and macrosomia. A valid triglyceride meter would allow the examination of maternal postprandial triglycerides in a systematic manner. A non-fasting venous and two capillary measurements (using the Roche Accutrend® Plus meter) of triglycerides were measured in 40 participants at a mean of 36 weeks gestation.

FINDINGS

The two methods were highly correlated (r = 0.89, P < 0.0001), and the distributions were similar (mean difference 0.01 mmol/L (SD 0.47)), t = 0.18, P =0.86). Passing Bablok equation was: y =  -0.01 + 0.98 × [95% CI intercept -0.51 - 0. 38; 95% CI slope 0.85-1.15). The estimated bias was -0.01 mmol/L (95% CI -0.93 - 0.91)).

CONCLUSIONS

This study demonstrated the Accutrend® Plus meter provides results that correlate strongly with the reference method, with low bias, when used in late pregnancy.