Okano Hideyuki, Mitra Partha
Laboratory for Marmoset Neural Architecture, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, United States.
Neurosci Res. 2015 Apr;93:3-7. doi: 10.1016/j.neures.2014.08.014. Epub 2014 Sep 27.
Globally, there is an increasing interest in brain-mapping projects, including the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative project in the USA, the Human Brain Project (HBP) in Europe, and the Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) project in Japan. These projects aim to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain. Brain/MINDS is focused on structural and functional mapping of the common marmoset (Callithrix jacchus) brain. This non-human primate has numerous advantages for brain mapping, including a well-developed frontal cortex and a compact brain size, as well as the availability of transgenic technologies. In the present review article, we discuss strategies for structural and functional mapping of the marmoset brain and the relation of the common marmoset to other animals models.
在全球范围内，人们对脑图谱项目的兴趣与日俱增，其中包括美国的“通过推动创新神经技术开展脑研究”（BRAIN）计划项目、欧洲的“人类脑计划”（HBP）以及日本的“用于疾病研究的综合神经技术脑图谱”（Brain/MINDS）项目。这些项目旨在绘制神经元回路的结构和功能图谱，以最终理解人类大脑的巨大复杂性。Brain/MINDS专注于普通狨猴（Callithrix jacchus）大脑的结构和功能图谱绘制。这种非人类灵长类动物在脑图谱研究方面具有诸多优势，包括发育良好的额叶皮质、紧凑的脑容量以及转基因技术的可用性。在本综述文章中，我们讨论了狨猴大脑结构和功能图谱绘制的策略以及普通狨猴与其他动物模型的关系。
