Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China; Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China.
Cell Rep. 2023 May 30;42(5):112480. doi: 10.1016/j.celrep.2023.112480. Epub 2023 May 9.
The cerebellum is essential for motor control and cognitive functioning, engaging in bidirectional communication with the cerebral cortex. The common marmoset, a small non-human primate, offers unique advantages for studying cerebello-cerebral circuits. However, the marmoset cerebellum is not well described in published resources. In this study, we present a comprehensive atlas of the marmoset cerebellum comprising (1) fine-detailed anatomical atlases and surface-analysis tools of the cerebellar cortex based on ultra-high-resolution ex vivo MRI, (2) functional connectivity and gradient patterns of the cerebellar cortex revealed by awake resting-state fMRI, and (3) structural-connectivity mapping of cerebellar nuclei using high-resolution diffusion MRI tractography. The atlas elucidates the anatomical details of the marmoset cerebellum, reveals distinct gradient patterns of intra-cerebellar and cerebello-cerebral functional connectivity, and maps the topological relationship of cerebellar nuclei in cerebello-cerebral circuits. As version 5 of the Marmoset Brain Mapping project, this atlas is publicly available at https://marmosetbrainmapping.org/MBMv5.html.
小脑对于运动控制和认知功能至关重要，它与大脑皮层进行双向通信。小型非人类灵长类动物——普通狨猴，为研究小脑-大脑回路提供了独特的优势。然而，在已发表的资料中，对狨猴小脑的描述并不完善。在这项研究中，我们提供了一份全面的狨猴小脑图谱，包括：(1) 基于超高分辨率离体 MRI 的小脑皮质精细详细解剖图谱和表面分析工具；(2) 通过清醒静息态 fMRI 揭示的小脑皮质功能连接和梯度模式；(3) 使用高分辨率弥散 MRI 轨迹描绘小脑核的结构连接图。该图谱阐明了狨猴小脑的解剖细节，揭示了小脑内和小脑-大脑功能连接的明显梯度模式，并描绘了小脑核在小脑-大脑回路中的拓扑关系。作为 Marmoset Brain Mapping 项目的第 5 版，该图谱可在 https://marmosetbrainmapping.org/MBMv5.html 上公开获取。
