身高作为结直肠癌的一个独立人体测量风险因素。
Height as an independent anthropomorphic risk factor for colorectal cancer.
作者信息
Boursi Ben, Haynes Kevin, Mamtani Ronac, Yang Yu-Xiao
机构信息
aDepartment of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine bDivision of Gastroenterology cDivision of Hematology/Medical Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA dThe Integrated Cancer Prevention Center, Tel-Aviv Sourasky Medical Center eTel-Aviv University, Tel-Aviv, Israel.
出版信息
Eur J Gastroenterol Hepatol. 2014 Dec;26(12):1422-7. doi: 10.1097/MEG.0000000000000209.
BACKGROUND
Previous studies have shown an association between height and colorectal cancer (CRC). None of those studies adjusted the association for known risk factors, such as diabetes mellitus and chronic exposure to aspirin/NSAIDs. Only two studies evaluated the risk among male individuals.
METHODS
We conducted a nested case-control study using a large population-based medical record database from the UK. Studied cases had any CRC code after the age of 40 years. Participants with a known family history of CRC syndromes or inflammatory bowel disease were excluded from the study. For every case, up to four eligible controls matched for age, sex, practice site, and duration of follow-up before the index date were selected by incidence-density sampling. Height was defined as the last measurement before the index date. The odds ratios (ORs) and 95% confidence intervals (CIs) for CRC were calculated for height quartiles, as well as for every 10-cm increase in height, using conditional logistic regression analysis, and adjusted for potential confounders.
RESULTS
A total of 9978 cases and 26 847 controls were identified. The adjusted OR for CRC in the participants at the highest compared with the lowest height quartiles was 1.25 for male (95% CI 1.14-1.37) and 1.25 for female (95% CI 1.12-1.39) individuals. The adjusted OR associated with each 10-cm increase in height was 1.10 (95% CI 1.05-1.15) for male and 1.16 (95% CI 1.10-1.23) for female individuals. The risk remained persistent when analyzing different age groups.
CONCLUSION
Height is an independent risk factor for CRC in both male and female individuals.
背景
既往研究表明身高与结直肠癌（CRC）之间存在关联。但这些研究均未对糖尿病和长期服用阿司匹林/非甾体抗炎药等已知风险因素进行校正。仅有两项研究评估了男性个体的风险。
方法
我们利用英国一个基于人群的大型医疗记录数据库开展了一项巢式病例对照研究。研究对象为40岁以后出现任何CRC编码的患者。有CRC综合征或炎症性肠病家族史的参与者被排除在研究之外。对于每例病例，通过发病密度抽样选择最多4名符合条件的对照，这些对照在索引日期之前按年龄、性别、执业地点和随访时间进行匹配。身高定义为索引日期之前的最后一次测量值。使用条件逻辑回归分析计算身高四分位数以及身高每增加10厘米时CRC的比值比（OR）和95%置信区间（CI），并对潜在混杂因素进行校正。
结果
共识别出9978例病例和26847名对照。身高最高四分位数组与最低四分位数组的参与者相比，男性CRC的校正OR为1.25（95%CI 1.14-1.37），女性为1.25（95%CI 1.12-1.39）。男性身高每增加10厘米的校正OR为1.10（95%CI 1.05-1.15），女性为1.16（95%CI 1.10-1.23）。在分析不同年龄组时，该风险仍然存在。
结论
身高是男性和女性CRC的独立危险因素。
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