亚洲成年人身高与癌症死亡率：亚太队列研究协作组。
Adult height and cancer mortality in Asia: the Asia Pacific Cohort Studies Collaboration.
机构信息
Medical Research Council Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK; The George Institute for International Health, University of Sydney, Sydney, Australia.
The George Institute for International Health, University of Sydney, Sydney, Australia.
出版信息
Ann Oncol. 2010 Mar;21(3):646-654. doi: 10.1093/annonc/mdp363. Epub 2009 Nov 4.
BACKGROUND
The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between height and a series of malignancies in Australasian (Caucasian) and Asian populations.
METHODS
Analyses were based on the Asia Pacific Cohort Studies Collaboration of 506 648 study participants (408 381 Asia, 98 267 Australasia) drawn from 38 population-based cohort studies. Cox proportional hazards regression was used to estimate the relationship between height and cancer rates.
RESULTS
A total of 3 272 600 person-years of follow-up gave rise to 7497 cancer deaths (4415 in Asia; 3082 in Australasia). After multiple adjustments and left censoring, taller individuals experienced increased rates of carcinoma of the intestine (men and women); all cancers, liver, lung, breast, 'other' malignancies (all women); and cancers of the prostate and bladder (men). No consistent regional (Asia versus Australasia) or sex differences were observed.
CONCLUSIONS
In the present study, taller men and women had an elevated risk of selected malignancies. These associations did not differ appreciably between Asian and Caucasian populations.
背景
身高较高的人罹患某些特定癌症风险增加的这一观察结果主要局限于白种人群体。这些关联在亚洲人群体中可能存在明显差异。我们首次在同一分析中对澳大利亚/亚洲人群中身高与一系列恶性肿瘤之间的关联进行了直接比较。
方法
分析基于亚太队列研究协作组织的 506648 名研究参与者（亚洲 408381 名，澳大利亚/亚洲 98267 名），来自 38 项基于人群的队列研究。采用 Cox 比例风险回归估计身高与癌症发病率之间的关系。
结果
共随访 3272600 人年，发生 7497 例癌症死亡（亚洲 4415 例；澳大利亚/亚洲 3082 例）。经过多次调整和左删失后，较高的个体经历了肠癌（男性和女性）；所有癌症、肝脏、肺、乳房、“其他”恶性肿瘤（所有女性）；以及前列腺癌和膀胱癌（男性）的发病率增加。未观察到明显的区域性（亚洲与澳大利亚/亚洲）或性别差异。
结论
在本研究中，较高的男性和女性罹患某些特定恶性肿瘤的风险增加。这些关联在亚洲和白种人群体中没有明显差异。
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