Hebuterne Xavier, Filippi Jerome, Schneider Stephane M
Service de Gastro-entérologie et Nutrition Clinique Hôpital de l'Archet 2, CHU de Nice 06202 Nice cedex 03, France.
Curr Drug Targets. 2014;15(11):1030-8. doi: 10.2174/1389450115666140930150047.
Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesity. IBD patients have many vitamin and nutrient deficiencies, which can lead to important consequences such as hyperhomocysteinemia, which is associated with a higher risk of thromboembolic disease. Nutritional deficiencies in IBD patients are the result of insufficient intake, malabsorption and protein-losing enteropathy as well as metabolic disturbances directly induced by the chronic disease and its treatments, in particular corticosteroids. Screening for nutritional deficiencies in chronic disease patients is warranted. Managing the deficiencies involves simple nutritional guidelines, vitamin supplements, and nutritional support in the worst cases.
75%的克罗恩病住院患者存在营养不良。三分之一的克罗恩病患者体重指数低于20。60%的克罗恩病患者存在肌肉减少症。然而,一些炎症性肠病(IBD)患者肥胖或患有肌肉减少性肥胖。IBD患者存在多种维生素和营养素缺乏,这可能导致重要后果,如高同型半胱氨酸血症,其与血栓栓塞性疾病的较高风险相关。IBD患者的营养缺乏是摄入不足、吸收不良、蛋白丢失性肠病以及慢性病及其治疗(特别是皮质类固醇)直接引起的代谢紊乱的结果。对慢性病患者进行营养缺乏筛查是有必要的。管理这些缺乏症涉及简单的营养指南、维生素补充剂,在最严重的情况下还需要营养支持。