Kim Seong-Eun
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Intest Res. 2019 Oct;17(4):443-454. doi: 10.5217/ir.2019.00075. Epub 2019 Sep 4.
The gut is an immune-microbiome-epithelial complex. Gut microbiome-host interactions have widespread biological implications, and the role of this complex system extends beyond the digestion of food and nutrient absorption. Dietary nutrients can affect this complex and play a key role in determining gut homeostasis to maintain host health. In this article, we review various dietary nutrients and their contribution to the pathogenesis and treatment of various intestinal diseases including inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, and diverticulitis, among other such disorders. A better understanding of diet-host-gut microbiome interactions is essential to provide beneficial nutrients for gut health and to limit nutritional hazards to ensure successful nutritional management of gastrointestinal conditions in clinical practice.
肠道是一个免疫-微生物群-上皮复合体。肠道微生物群与宿主的相互作用具有广泛的生物学意义，这个复杂系统的作用不仅限于食物消化和营养吸收。膳食营养素会影响这个复合体，并在决定肠道内环境稳定以维持宿主健康方面发挥关键作用。在本文中，我们综述了各种膳食营养素及其在包括炎症性肠病、肠易激综合征、结直肠癌和憩室炎等多种肠道疾病的发病机制和治疗中的作用。更好地理解饮食-宿主-肠道微生物群的相互作用对于为肠道健康提供有益营养素以及限制营养危害至关重要，以便在临床实践中成功进行胃肠道疾病的营养管理。
