Bhat T K, Sharma R L, Jithendran K P
Int J Parasitol. 1989 May;19(3):349-51. doi: 10.1016/0020-7519(89)90148-3.
The pathogenesis of Dictyocaulus filaria induced anaemia was experimentally investigated. Nineteen Dorset-Muzaffarnagri male lambs were divided into two groups of 13 and six. The lambs in the former group received a primary infection dose of 2000 D. filaria infective larvae, whereas animals in the latter group were kept as uninfected controls. The haematological alterations and faecal larval output were monitored weekly until day 220 post-infection. The infection caused an increase in erythrocyte sedimentation rate (ESR) and total leukocyte count (TLC). However, a decrease in packed cell volume (PCV), haemoglobin, total erythrocyte count (TEC) and blood pH was observed in acute infection. The shape and size of the erythrocytes, serum bilirubin level, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) remained unaffected In carriers, except for TEC, the values of these parameters returned to near-normal levels. The analysis of the results suggests that the infected animals developed a normocytic normochromic anaemia which persisted during the later stage of infection.
对丝状网尾线虫引起贫血的发病机制进行了实验研究。19只多塞特-穆扎法尔纳格里雄性羔羊被分为两组，一组13只，另一组6只。前一组羔羊接受2000条丝状网尾线虫感染性幼虫的初次感染剂量，而后一组动物作为未感染对照。每周监测血液学变化和粪便幼虫排出量，直至感染后第220天。感染导致红细胞沉降率（ESR）和白细胞总数（TLC）增加。然而，在急性感染期观察到红细胞压积（PCV）、血红蛋白、红细胞总数（TEC）和血液pH值下降。红细胞的形状和大小、血清胆红素水平、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和平均红细胞血红蛋白浓度（MCHC）均未受影响。在带虫羊中，除TEC外，这些参数的值恢复到接近正常水平。结果分析表明，受感染动物出现了正细胞正色素性贫血，且在感染后期持续存在。
