Bhat T K, Sharma R L
Int J Parasitol. 1989 Dec;19(8):953-5. doi: 10.1016/0020-7519(89)90127-6.
Alterations in the sheep erythrocyte membrane constituents during the course of Dictyocaulus filaria infection were studied in 4-6 month old Nali lambs. During the acute course of infection, plasma cholesterol, membrane cholesterol, cholesterol: phospholipid ratio and acetylcholinesterase activity fell significantly when compared with uninfected controls. The onset of the fall in the values of these parameters was observed 1-2 weeks prior to an increase in the osmotic fragility of erythrocytes. The altered values persistently remained at sub-normal levels during the chronic stage of the infection. However, the membrane proteins and phospholipids of sheep erythrocytes remained unaffected during the entire period of study. The clinico-parasitological picture of the disease, as judged by the clinical course of disease, faecal larval output and necropsy worm recovery, was typical of ovine dictyocauliosis.
在4至6月龄的纳里羔羊中研究了丝状网尾线虫感染过程中绵羊红细胞膜成分的变化。在感染的急性期，与未感染的对照组相比，血浆胆固醇、膜胆固醇、胆固醇与磷脂的比率以及乙酰胆碱酯酶活性显著下降。在红细胞渗透脆性增加前1至2周观察到这些参数值开始下降。在感染的慢性阶段，这些改变的值持续保持在低于正常的水平。然而，在整个研究期间，绵羊红细胞的膜蛋白和磷脂未受影响。根据疾病的临床病程、粪便幼虫排出量和尸检蠕虫回收率判断，该病的临床寄生虫学表现是典型的绵羊网尾线虫病。
