Fehér Ágnes, Juhász Anna, Pákáski Magdolna, Kálmán János, Janka Zoltán
Department of Psychiatry, University of Szeged, 57 Kálvária Ave, Szeged, 6724, Hungary,
J Mol Neurosci. 2014 Dec;54(4):826-9. doi: 10.1007/s12031-014-0427-z. Epub 2014 Oct 2.
To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer's disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.
为评估ATP结合盒亚家族B成员1（ABCB1）基因变异与阿尔茨海默病（AD）易感性之间的关联，我们对一个病例对照样本（234例AD患者，225例对照）中的rs1128503（C1236T）、rs2032582（G2677T/A）和rs1045642（C3435T）多态性进行了基因分型。单标记分析显示仅rs1045642多态性存在显著关联（C/C基因型携带者患AD的风险增加），在进行多重检验校正后该关联仍具有显著性。单倍型分析表明有三个名义上显著的关联，在应用多重检验校正后这些关联消失了。
