Faculty of Applied Health Sciences, Brock University, St. Catharine's, Ontario, Canada.
Neurosci Lett. 2011 Jan 10;487(3):389-93. doi: 10.1016/j.neulet.2010.10.063. Epub 2010 Oct 31.
The pathogenesis of Alzheimer's disease (AD) senile plaque (SP) and neurofibrillary tangle (NFT) lesions putatively involves a compromised blood-brain barrier (BBB). P-glycoprotein (P-gp) is a recognized BBB-related efflux transporter protein. In this investigation we determined the density of SP and NFT lesions and capillary densities stained positively for P-glycoprotein (P-gp), and other transport proteins, in AD and control group (CG) brain samples. Our results indicate that there are significant negative correlations (p<.01) between the densities of NFT and SP(40) lesions and P-gp positive capillaries in AD but not CG brain samples. Significant positive correlations (p<.01) were observed between the densities of P-gp positive capillaries and LRP and RAGE positive capillaries in both AD and CG brains. These results also suggest that the levels of capillary P-gp may contribute to AD lesion development and that the role of P-gp is associated with that of LRP and RAGE.
阿尔茨海默病（AD）老年斑（SP）和神经原纤维缠结（NFT）病变的发病机制推测涉及血脑屏障（BBB）受损。P-糖蛋白（P-gp）是一种公认的与 BBB 相关的外排转运蛋白。在这项研究中，我们确定了 AD 和对照组（CG）脑样本中 SP 和 NFT 病变的密度以及阳性染色的 P-糖蛋白（P-gp）和其他转运蛋白的毛细血管密度。我们的结果表明，AD 脑样本中 NFT 和 SP（40）病变的密度与 P-gp 阳性毛细血管之间存在显著负相关（p<.01），但 CG 脑样本中没有。在 AD 和 CG 脑样本中，P-gp 阳性毛细血管与 LRP 和 RAGE 阳性毛细血管的密度之间均存在显著正相关（p<.01）。这些结果还表明，毛细血管 P-gp 的水平可能有助于 AD 病变的发展，并且 P-gp 的作用与 LRP 和 RAGE 相关。
