Rudd Rose A, Paulozzi Len J, Bauer Michael J, Burleson Richard W, Carlson Rick E, Dao Dan, Davis James W, Dudek Jennifer, Eichler Beth Ann, Fernandes Jessie C, Fondario Anna, Gabella Barbara, Hume Beth, Huntamer Theron, Kariisa Mbabazi, Largo Thomas W, Miles JoAnne, Newmyer Ashley, Nitcheva Daniela, Perez Beatriz E, Proescholdbell Scott K, Sabel Jennifer C, Skiba Jessica, Slavova Svetla, Stone Kathy, Tharp John M, Wendling Tracy, Wright Dagan, Zehner Anne M
MMWR Morb Mortal Wkly Rep. 2014 Oct 3;63(39):849-54.
Nationally, death rates from prescription opioid pain reliever (OPR) overdoses quadrupled during 1999-2010, whereas rates from heroin overdoses increased by <50%. Individual states and cities have reported substantial increases in deaths from heroin overdose since 2010. CDC analyzed recent mortality data from 28 states to determine the scope of the heroin overdose death increase and to determine whether increases were associated with changes in OPR overdose death rates since 2010. This report summarizes the results of that analysis, which found that, from 2010 to 2012, the death rate from heroin overdose for the 28 states increased from 1.0 to 2.1 per 100,000, whereas the death rate from OPR overdose declined from 6.0 per 100,000 in 2010 to 5.6 per 100,000 in 2012. Heroin overdose death rates increased significantly for both sexes, all age groups, all census regions, and all racial/ethnic groups other than American Indians/Alaska Natives. OPR overdose mortality declined significantly among males, persons aged <45 years, persons in the South, and non-Hispanic whites. Five states had increases in the OPR death rate, seven states had decreases, and 16 states had no change. Of the 18 states with statistically reliable heroin overdose death rates (i.e., rates based on at least 20 deaths), 15 states reported increases. Decreases in OPR death rates were not associated with increases in heroin death rates. The findings indicate a need for intensified prevention efforts aimed at reducing overdose deaths from all types of opioids while recognizing the demographic differences between the heroin and OPR-using populations. Efforts to prevent expansion of the number of OPR users who might use heroin when it is available should continue.
在全国范围内,1999年至2010年期间,处方阿片类镇痛药(OPR)过量致死率增长了两倍,而海洛因过量致死率增长不到50%。自2010年以来,个别州和城市报告称海洛因过量致死人数大幅增加。美国疾病控制与预防中心(CDC)分析了28个州最近的死亡率数据,以确定海洛因过量致死人数增加的范围,并确定自2010年以来这种增加是否与OPR过量致死率的变化有关。本报告总结了该分析结果,结果发现,从2010年到2012年,28个州的海洛因过量致死率从每10万人1.0例增至2.1例,而OPR过量致死率则从2010年的每10万人6.0例降至2012年的每10万人5.6例。海洛因过量致死率在所有性别、所有年龄组、所有人口普查地区以及除美洲印第安人/阿拉斯加原住民以外的所有种族/族裔群体中均显著上升。OPR过量致死率在男性、45岁以下人群、南方人群以及非西班牙裔白人中显著下降。五个州的OPR死亡率上升,七个州下降,16个州无变化。在18个海洛因过量致死率具有统计学可靠性的州(即基于至少20例死亡的比率)中,15个州报告有所上升。OPR死亡率的下降与海洛因死亡率的上升无关。研究结果表明,需要加强预防工作,以减少各类阿片类药物过量致死情况,同时认识到使用海洛因人群和使用OPR人群之间的人口统计学差异。应继续努力防止可能在有海洛因时使用海洛因的OPR使用者数量增加。