van der Vange N, van der Berg H, Kloosterboer H J, Haspels A A
Department of Gynaecology, University Hospital of Utrecht, The Netherlands.
Contraception. 1989 Sep;40(3):377-84. doi: 10.1016/0010-7824(89)90100-5.
The effect of seven low-dose oral contraceptive preparations on vitamin B6 status was investigated in 55 women. All preparations contained about the same amount of ethinylestradiol but differed in the content and type of progestagen. The following preparations were investigated: monophasic and triphasic levonorgestrel, monophasic and biphasic desogestrel, monophasic norethisterone, monophasic cyproterone acetate and triphasic gestodene. The vitamin B6 status was evaluated by measuring erythrocyte glutamate oxaloacetate transaminase (EGOT) activity and its degree of in vitro stimulation. From these two variables the total EGOT activity was calculated. In addition plasma pyridoxal-5'-phosphate (PLP) levels were estimated. After six months' treatment, EGOT activity and the calculated total EGOT activity were increased, but no changes were observed in the degree of in vitro stimulation (which is a more reliable parameter). Plasma PLP levels initially decreased during the first three months of treatment but after six months a return to normal levels was observed. Differences between the seven preparations were not found. We conclude from these results that the low-dose preparations investigated in this study have no any adverse effects on vitamin B6 status.
在55名女性中研究了七种低剂量口服避孕药制剂对维生素B6状态的影响。所有制剂含有的炔雌醇量大致相同，但孕激素的含量和类型有所不同。研究了以下制剂：单相和三相左炔诺孕酮、单相和双相去氧孕烯、单相炔诺酮、单相醋酸环丙孕酮和三相孕二烯酮。通过测量红细胞谷氨酸草酰乙酸转氨酶（EGOT）活性及其体外刺激程度来评估维生素B6状态。根据这两个变量计算出总EGOT活性。此外，还测定了血浆5'-磷酸吡哆醛（PLP）水平。治疗六个月后，EGOT活性和计算出的总EGOT活性增加，但体外刺激程度（这是一个更可靠的参数）未观察到变化。治疗的前三个月血浆PLP水平最初下降，但六个月后观察到恢复到正常水平。未发现七种制剂之间存在差异。从这些结果我们得出结论，本研究中所研究的低剂量制剂对维生素B6状态没有任何不良影响。
