Hsu Jen-Yi, Ho Hsin-Hui, Liao Pao-Chi
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan; Analytical Center, Chia Nan University of Pharmacy and Science, 60 Sec. 1, Erren Road, Rende Dist., Tainan 717, Taiwan.
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan.
Chemosphere. 2015 Jan;118:219-28. doi: 10.1016/j.chemosphere.2014.09.025. Epub 2014 Sep 29.
Diisononyl phthalate (DINP) is a widely used industrial plasticizer. People come into contact with this chemical by using plastic products made with it. Human health can be adversely affected by long-term DINP exposure. However, because the body rapidly excretes DINP metabolites, the use of single-point urine analysis to assess long-term exposure may produce inconsistent results in epidemiologic studies. Hair analysis has a useful place in biomonitoring, particularly in estimating long-term or historical exposure for some chemicals. Several studies have reported using hair analysis to assess the concentrations of heavy metals, drugs and organic pollutants in humans. As a biomarker, DINP metabolites were measured in rat hair in animal experiments to evaluated long-term exposure to DINP. In addition, we evaluated the correlation between the levels of DINP metabolites in hair and in urine. The levels of DINP metabolites in rat hair were significantly higher in the exposure group, relative to the control group (p<0.05). DINP metabolites had a positive correlation with increasing administered dose. Significant positive correlations for MINP, MOINP and MHINP were found between hair and urine (r=0.86, r=0.79 and r=0.74, respectively, p<0.05). Several metabolites in urine showed earlier saturation than in hair. In this report, we detected eight metabolites in hair and demonstrate that hair analysis has potential applications in the assessment of long-term exposure to DINP.
邻苯二甲酸二异壬酯（DINP）是一种广泛使用的工业增塑剂。人们通过使用含有该化学物质的塑料制品而接触到它。长期接触DINP会对人体健康产生不利影响。然而，由于人体会迅速排出DINP代谢物，因此在流行病学研究中，使用单点尿液分析来评估长期接触情况可能会得出不一致的结果。头发分析在生物监测中具有重要作用，特别是在估计某些化学物质的长期或历史接触情况方面。多项研究报告了使用头发分析来评估人体中重金属、药物和有机污染物的浓度。作为一种生物标志物，在动物实验中对大鼠毛发中的DINP代谢物进行了测量，以评估长期接触DINP的情况。此外，我们还评估了毛发和尿液中DINP代谢物水平之间的相关性。与对照组相比，暴露组大鼠毛发中DINP代谢物的水平显著更高（p<0.05）。DINP代谢物与给药剂量的增加呈正相关。在毛发和尿液之间发现MINP、MOINP和MHINP存在显著正相关（r分别为0.86、0.79和0.74，p<0.05）。尿液中的几种代谢物比毛发中的更早达到饱和。在本报告中，我们在毛发中检测到了八种代谢物，并证明头发分析在评估长期接触DINP方面具有潜在应用价值。
