Hsu Jen-Yi, Shih Chia-Lung, Liao Pao-Chi
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University.
Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0062. doi: 10.5702/massspectrometry.S0062. Epub 2017 Mar 24.
Phthalates are chemicals widely used in industry and the consequences on human health caused by exposure to these agents are of significant interest currently. The urinary metabolites of phthalates can be measured and used as exposure markers for the assessment of the actual internal contamination of phthalates coming from different sources and absorbed by various ways. The purpose of this paper is to review the markers for exposure and risk assessment of phthalates such as di-methyl phthalate (DMP), di-ethyl phthalate (DEP), di-butyl phthalate (DBP), benzylbutyl phthalate (BBP), di-(2-ethylhexyl)phthalate (DEHP), di-(2-propylheptyl)phthalate (DPHP), di-iso-nonyl phthalate (DINP), di--octyl phthalate (DOP) and di-iso-decyl phthalate (DIDP), and introduction of the analytical approach of three metabolomics data processing approaches that can be used for chemical exposure marker discovery in urine with high-resolution mass spectrometry (HRMS) data.
邻苯二甲酸盐是工业中广泛使用的化学物质，目前人们对接触这些物质对人类健康造成的影响极为关注。邻苯二甲酸盐的尿液代谢物可以被测量，并用作暴露标志物，以评估来自不同来源并通过各种方式吸收的邻苯二甲酸盐的实际体内污染情况。本文的目的是综述邻苯二甲酸二甲酯（DMP）、邻苯二甲酸二乙酯（DEP）、邻苯二甲酸二丁酯（DBP）、邻苯二甲酸苄基丁酯（BBP）、邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二（2-丙基庚基）酯（DPHP）、邻苯二甲酸二异壬酯（DINP）、邻苯二甲酸二辛酯（DOP）和邻苯二甲酸二异癸酯（DIDP）等邻苯二甲酸盐的暴露和风险评估标志物，并介绍三种代谢组学数据处理方法的分析方法，这些方法可用于通过高分辨率质谱（HRMS）数据发现尿液中的化学暴露标志物。
