Gkountela Sofia, Clark Amander T
Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell Stem Cell. 2014 Oct 2;15(4):393-394. doi: 10.1016/j.stem.2014.09.005.
In stem cell biology, the dynamic addition and removal of 5-methylcytosines (5mCs) are necessary for lineage differentiation, nuclear reprogramming, and embryonic development. Recent investigations have sought to understand the mechanisms of how 5mCs are added and in particular how 5mCs are removed from DNA during embryogenesis.
在干细胞生物学中,5-甲基胞嘧啶(5mC)的动态添加和去除对于细胞谱系分化、核重编程及胚胎发育而言是必要的。最近的研究试图了解5mC是如何添加的,尤其是在胚胎发生过程中5mC是如何从DNA上去除的机制。