小受精卵中的大惊喜：丢失甲基化胞嘧啶的奇妙过程。
A big surprise in the little zygote: the curious business of losing methylated cytosines.
作者信息
Gkountela Sofia, Clark Amander T
机构信息
Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Cell Stem Cell. 2014 Oct 2;15(4):393-394. doi: 10.1016/j.stem.2014.09.005.
Abstract
In stem cell biology, the dynamic addition and removal of 5-methylcytosines (5mCs) are necessary for lineage differentiation, nuclear reprogramming, and embryonic development. Recent investigations have sought to understand the mechanisms of how 5mCs are added and in particular how 5mCs are removed from DNA during embryogenesis.
摘要
在干细胞生物学中，5-甲基胞嘧啶（5mC）的动态添加和去除对于细胞谱系分化、核重编程及胚胎发育而言是必要的。最近的研究试图了解5mC是如何添加的，尤其是在胚胎发生过程中5mC是如何从DNA上去除的机制。
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2
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Cell. 2014 May 8;157(4):979-991. doi: 10.1016/j.cell.2014.04.017.
3
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.在小鼠胚胎植入前发育过程中，5fC 和 5caC 的产生和复制依赖性稀释。
Cell Res. 2011 Dec;21(12):1670-6. doi: 10.1038/cr.2011.189. Epub 2011 Nov 29.
4
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5
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6
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.Tet 介导的哺乳动物 DNA 中 5-羧基胞嘧啶的形成及其由 TDG 切除。
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7
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