Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Centre for Stem Cells and Regenerative Medicine and Institute for Liver Studies, Kings College London, SE1 9RT, UK.
Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.
Cell Stem Cell. 2014 Oct 2;15(4):406-409. doi: 10.1016/j.stem.2014.09.013.
While cell therapies hold great potential for treating many conditions, their utility for treating patients that require whole organ replacement is unclear. To address this challenge, we propose using genetically engineered "organ niches" in large animals to generate human organs from pluripotent stem cells and discuss the hurdles facing such strategies.
虽然细胞疗法在治疗许多疾病方面具有巨大的潜力，但它们在治疗需要整个器官替代的患者方面的效用尚不清楚。为了解决这一挑战，我们提出利用大型动物中的基因工程“器官龛”，从多能干细胞中生成人类器官，并讨论这些策略所面临的障碍。
