人类多能干细胞的原始状态：干细胞与植入前胚胎转录组分析的综合研究
The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses.
作者信息
Huang Kevin, Maruyama Toru, Fan Guoping
机构信息
Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA.
Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA; Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.
出版信息
Cell Stem Cell. 2014 Oct 2;15(4):410-415. doi: 10.1016/j.stem.2014.09.014.
Abstract
Here we use a systems biology approach to comprehensively assess the conservation of gene networks in naive pluripotent stem cells (PSCs) with preimplantation embryos. While gene networks in murine naive and primed pluripotent states are reproducible across data sets, different sources of human stem cells display high degrees of variation, partly reflecting disparities in culture conditions. Finally, naive gene networks between human and mouse PSCs are not well conserved and better resemble their respective blastocysts.
摘要
在这里，我们采用系统生物学方法，全面评估原始多能干细胞（PSC）与植入前胚胎中基因网络的保守性。虽然小鼠原始和已分化多能状态下的基因网络在不同数据集中具有可重复性，但不同来源的人类干细胞表现出高度的变异性，部分反映了培养条件的差异。最后，人类和小鼠PSC之间的原始基因网络保守性不佳，且更类似于它们各自的囊胚。
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